Sermorelin vs Tesamorelin
Both are GHRH analogs that stimulate natural growth hormone production, but they differ in potency, regulatory status, and clinical applications.
| Metric | Sermorelin | Tesamorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Default Unit | mcg | mg |
| Vial Sizes | 3, 6, 9, 15 | 2, 5, 10 |
| Dose Range | 100–500 mcg | 1–2 mg |
| Frequency | Daily before bed | Daily (PM) |
| Stability | 28 days | 28 days |
| Powder Storage | Freezer −20°C | Freezer −20°C |
| Reconstituted | Fridge 2–8°C | Fridge 2–8°C |
Potency
Tesamorelin is significantly more potent than sermorelin on a milligram-for-milligram basis. It produces greater IGF-1 elevation and more pronounced visceral fat reduction in clinical trials. Sermorelin is the milder option with a gentler effect profile.
FDA Status
Tesamorelin (Egrifta) is FDA-approved for HIV-associated lipodystrophy — the only FDA-approved GHRH peptide. Sermorelin was previously FDA-approved (Geref) but the commercial product was discontinued in 2008. Both are available through compounding pharmacies with a prescription.
Dosing
Sermorelin: 100–500 mcg daily (micrograms). Tesamorelin: 1–2 mg daily (milligrams). Despite the different absolute amounts, tesamorelin's greater potency means it produces stronger GH stimulation per dose.
Best Use Cases
Sermorelin: first-line GH peptide for beginners, anti-aging protocols, those wanting gentle GH support with minimal risk. Tesamorelin: visceral fat reduction, stronger GH stimulation needed, users who didn't respond adequately to sermorelin.
⚖️ The Verdict
Start with sermorelin if you're new to GH peptides — it's milder with the longest safety track record. Move to tesamorelin if you need stronger GH stimulation or specific visceral fat reduction. Both are legitimate GHRH options; they just sit at different points on the potency spectrum.
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