What is TB-500?
TB-500 is a synthetic version of Thymosin Beta-4 (TΞ²4), a 43-amino acid protein naturally present in most human cells. Thymosin Beta-4 plays a critical role in cell migration, blood vessel formation, and tissue repair. TB-500 replicates the active region of this protein for research applications.
How TB-500 Works
TB-500 upregulates actin, a cell-building protein involved in cell migration and proliferation. This allows cells to move more efficiently to sites of injury. It also promotes angiogenesis (formation of new blood vessels) and reduces inflammation. Unlike BPC-157 which is often injected locally, TB-500 is always administered systemically β it doesn't need to be near the injury site.
How to Reconstitute TB-500
TB-500 is dosed in milligrams, not micrograms. Doses are significantly larger than BPC-157 in absolute terms.
- 2 mg vial β 1 mL BAC water (2 mg/mL)
- 5 mg vial β 2 mL BAC water (2.5 mg/mL)
- 10 mg vial β 3 mL BAC water (3.33 mg/mL)
Common Protocols
Research protocols typically involve a loading phase and maintenance phase. Loading: 2β5 mg injected subcutaneously twice per week for 4β6 weeks. Maintenance: 2β5 mg once per week. Some protocols use higher loading doses (5β10 mg) for more severe injuries.
TB-500 vs BPC-157
BPC-157 (micrograms, local or systemic, tendon/gut focus) and TB-500 (milligrams, always systemic, inflammation/migration focus) address healing from different angles. They are frequently combined in what the research community calls a "healing stack." See our comparison tool for detailed side-by-side analysis.
Educational purposes only. Consult a healthcare professional.